| Day | Time (EDT) | Network | Team | vs. | Team |
| Thursday, March 16 | 12:15 PM | CBS | Notre Dame | vs. | Princeton |
| Thursday, March 16 | 12:40 PM | truTV | Virginia | vs. | UNC-Wilmington |
| Thursday, March 16 | 1:30 PM | TNT | Butler | vs. | Winthrop |
| Thursday, March 16 | 2:00 PM | TBS | Gonzaga | vs. | South Dakota St. |
| Thursday, March 16 | 2:45 PM | CBS | West Virginia | vs. | Bucknell |
| Thursday, March 16 | 3:10 PM | truTV | Florida | vs. | East Tennessee St. |
| Thursday, March 16 | 4:00 PM | TNT | Minnesota | vs. | Middle Tennessee |
| Thursday, March 16 | 4:30 PM | TBS | Northwestern | vs. | Vanderbilt |
| Thursday, March 16 | 6:50 PM | TNT | Maryland | vs. | Xavier |
| Thursday, March 16 | 7:10 PM | CBS | Villanova | vs. | Mt. St. Marys/UNO |
| Thursday, March 16 | 7:20 PM | TBS | Saint Mary’s | vs. | VCU |
| Thursday, March 16 | 7:27 PM | truTV | Purdue | vs. | Vermont |
| Thursday, March 16 | 9:20 PM | TNT | Florida St. | vs. | Florida Gulf Coast |
| Thursday, March 16 | 9:40 PM | CBS | Wisconsin | vs. | Virginia Tech |
| Thursday, March 16 | 9:50 PM | TBS | Arizona | vs. | North Dakota |
| Thursday, March 16 | 9:57 PM | truTV | Iowa St. | vs. | Nevada |
| Friday, March 17 | 12:15 PM | CBS | Michigan | vs. | Oklahoma St. |
| Friday, March 17 | 12:40 PM | truTV | Baylor | vs. | New Mexico St. |
| Friday, March 17 | 1:30 PM | TNT | Arkansas | vs. | Seton Hall |
| Friday, March 17 | 2:00 PM | TBS | Oregon | vs. | Iona |
| Friday, March 17 | 2:45 PM | CBS | Louisville | vs. | Jacksonville St. |
| Friday, March 17 | 3:10 PM | truTV | SMU | vs. | Providence/USC |
| Friday, March 17 | 4:00 PM | TNT | North Carolina | vs. | Texas Southern |
| Friday, March 17 | 4:30 PM | TBS | Creighton | vs. | Rhode Island |
| Friday, March 17 | 6:50 PM | TNT | Kansas | vs. | UNC-Cent./UC-Davis |
| Friday, March 17 | 7:10 PM | CBS | Dayton | vs. | Wichita St. |
| Friday, March 17 | 7:20 PM | TBS | Duke | vs. | Troy |
| Friday, March 17 | 7:27 PM | truTV | Cincinnati | vs. | Kan. St./Wake Forest |
| Friday, March 17 | 9:20 PM | TNT | Miami (Fla.) | vs. | Michigan St. |
| Friday, March 17 | 9:40 PM | CBS | Kentucky | vs. | Northern Kentucky |
| Friday, March 17 | 9:50 PM | TBS | South Carolina | vs. | Marquette |
| Friday, March 17 | 9:57 PM | truTV | UCLA | vs. | Kent St. |
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