| Wednesday, March 16, 2022 | ||
| Team | Team | Spread |
| Wright St. | Bryant | 0.7 |
| Rutgers | Notre Dame | -1.6 |
| Wake Forest | Towson | 7.0 |
| Toledo | Dayton | 0.3 |
| Virginia | Mississippi St. | -0.1 |
| SMU | Nicholls St. | 14.6 |
| Saint Louis | Northern Iowa | 5.1 |
| BYU | Long Beach St. | 11.8 |
| Florida | Iona | 7.1 |
| Coastal Carolina | Maryland Eastern Shore | 12.5 |
| Youngstown St. | Morgan St. | 5.5 |
| South Alabama | Southeast Louisiana | 10.7 |
| Florida Gulf Coast | Detroit | 3.6 |
| Maryland Baltimore Co. | Merrimack | 5.5 |
| Southern Utah | Kent St. | 1.6 |
March 16, 2022
PiRate Ratings College Basketball–Wednesday, March 16, 2022
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The Pi-Rate Ratings 