| Date | 3/7/2022 | |||||
| Seed | Team | Team | Team | Team | Team | Team |
| 1 | Arizona | Gonzaga | Baylor | Auburn | ||
| 2 | Kansas | Kentucky | Duke | Purdue | ||
| 3 | Wisconsin | Villanova | Tennessee | Texas Tech | ||
| 4 | Illinois | Providence | UCLA | Arkansas | ||
| 5 | Connecticut | Houston | Texas | Alabama | ||
| 6 | Saint Mary’s | LSU | Iowa | Ohio St. | ||
| 7 | Colorado St. | USC | Boise St. | Seton Hall | ||
| 8 | Michigan St. | Iowa St. | Murray St. | Marquette | ||
| 9 | North Carolina | San Diego St. | TCU | San Francisco | ||
| 10 | Creighton | Michigan | Loyola (Chi.) | Davidson | ||
| 11 | Miami (Fla.) | Memphis | Xavier | Notre Dame | ||
| 12 | South Dakota St. | North Texas | Wake Forest | Wyoming | Rutgers | SMU |
| 13 | Iona | Toledo | Chattanooga | Vermont | ||
| 14 | New Mexico St. | Princeton | Towson | Montana St. | ||
| 15 | Long Beach St. | Longwood | Jacksonville St. | Colgate | ||
| 16 | Georgia St. | Purdue Ft. Wayne | Bryant | Nicholls St. | Norfolk St. | Texas Southern |
Last 4 Byes
Miami (Fla.)
Memphis
Xavier
Notre Dame
Last Four In
Wake Forest
Wyoming
Rutgers
SMU
First Four Out
VCU
Indiana
BYU
Dayton
Next Four Out
Texas A&M
Florida
Virginia Tech
Saint Louis
The Pi-Rate Ratings 