| Date | 1/17/2022 | |||||
| Seed | Team | Team | Team | Team | Team | Team |
| 1 | Gonzaga | Arizona | Villanova | Auburn | ||
| 2 | Houston | Baylor | Kansas | LSU | ||
| 3 | Kentucky | Illinois | Purdue | Duke | ||
| 4 | Tennessee | Texas | Xavier | Connecticut | ||
| 5 | Wisconsin | Texas Tech | Iowa St. | UCLA | ||
| 6 | Iowa | Michigan St. | Alabama | Ohio St. | ||
| 7 | USC | Seton Hall | North Carolina | Indiana | ||
| 8 | Loyola (Chi.) | Providence | Oklahoma | Marquette | ||
| 9 | BYU | Colorado St. | West Virginia | Florida | ||
| 10 | San Diego St. | Mississippi St. | Wake Forest | Miami (Fla.) | ||
| 11 | Texas A&M | Oregon | TCU | Creighton | San Francisco | Saint Mary’s |
| 12 | Murray St. | Davidson | UAB | Chattanooga | ||
| 13 | Iona | Grand Canyon | Vermont | Oakland | ||
| 14 | Toledo | Towson | Wagner | South Dakota St. | ||
| 15 | UC-Irvine | Navy | Liberty | Princeton | ||
| 16 | Texas St. | Montana St. | Gardner-Webb | Texas Southern | Nicholls St. | Norfolk St. |
Last 4 Byes: Wake Forest, Miami (Fla.), Texas A&M, Oregon
Last 4 In: TCU, Creighton, San Francisco, Saint Mary’s
First 4 Out: Wyoming, Belmont, Arkansas, Michigan
Next 4 Out: Cincinnati, Virginia Tech, Boise St., St. Bonaventure
The Pi-Rate Ratings 