| Home | Visitors | Spread |
| Xavier | Villanova | 0.3 |
| Radford | Longwood | -2.3 |
| Wake Forest | Duke | -5.6 |
| Michigan St. | Minnesota | 11.1 |
| Florida | LSU | -2.9 |
| Tulsa | Temple | 3.3 |
| Central Florida | Memphis | -1.5 |
| Cincinnati | East Carolina | 10.9 |
| Morehead St. | UT Martin | 13.9 |
| North Carolina A&T | Hampton | 7.7 |
| Gardner-Webb | Presbyterian | 9.1 |
| Campbell | Charleston Southern | 16.3 |
| Notre Dame | Clemson | 0.9 |
| Vermont | Stony Brook | 11.1 |
| Albany | UMass Lowell | -2.2 |
| NJIT | UMBC | 0.9 |
| Rhode Island | Saint Joseph’s | 8.0 |
| Fordham | Duquesne | 1.9 |
| Western Carolina | Chattanooga | -13.5 |
| Wofford | Samford | 10.7 |
| Furman | East Tennessee St. | 8.3 |
| UNC Wilmington | Elon | 1.2 |
| Mississippi St. | Georgia | 15.0 |
| Norfolk St. | Delaware St. | 18.6 |
| USC Upstate | High Point | -1.8 |
| Colorado St. | Utah St. | 3.9 |
| Wichita St. | Tulane | 9.0 |
| SMU | South Florida | 15.2 |
| Missouri St. | Southern Illinois | 7.5 |
| Drake | Illinois St. | 10.8 |
| Bradley | Evansville | 9.4 |
| Connecticut | St. John’s | 10.6 |
| Louisville | NC St. | 7.3 |
| Virginia | Virginia Tech | -1.8 |
| Boston College | Georgia Tech | 0.6 |
| Kansas St. | TCU | 2.1 |
| Arkansas | Missouri | 12.5 |
| Northwestern | Maryland | 4.1 |
| Pacific | Santa Clara | -8.5 |
| Washington | California | -0.8 |
| California Baptist | Dixie St. | 8.6 |
| Seattle | Utah Valley | -1.1 |
| Nevada | Boise St. | -1.2 |
January 12, 2022
PiRate Ratings College Basketball–Wednesday, January 12, 2022
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The Pi-Rate Ratings 