| Date | 1/7/2022 | |||||
| Seed | Team | Team | Team | Team | Team | Team |
| 1 | Baylor | Gonzaga | Houston | Arizona | ||
| 2 | Kansas | Villanova | Auburn | LSU | ||
| 3 | Duke | Purdue | Texas | Tennessee | ||
| 4 | Illinois | Michigan St. | USC | Kentucky | ||
| 5 | Alabama | UCLA | Connecticut | Iowa St. | ||
| 6 | Wisconsin | Xavier | Ohio St. | Texas Tech | ||
| 7 | Loyola (Chi.) | Seton Hall | BYU | Indiana | ||
| 8 | Iowa | Colorado St. | W. Virginia | N. Carolina | ||
| 9 | Oklahoma | Va.Tech | San Francisco | Mississippi St. | ||
| 10 | Providence | TCU | Florida | Wake Forest | ||
| 11 | Saint Mary’s | Michigan | San Diego St. | Memphis | Texas A&M | Clemson |
| 12 | Chattanooga | Belmont | Davidson | UAB | ||
| 13 | Iona | Ohio | Vermont | Towson | ||
| 14 | Wagner | South Dakota St. | Navy | Oakland | ||
| 15 | Grand Canyon | UC-Irvine | Liberty | Princeton | ||
| 16 | Louisiana | Weber St. | Nicholls St. | Gardner-Webb | Texas Southern | Howard |
First Four Out
| Creighton |
| Louisville |
| Florida St. |
| Cincinnati |
Next Four Out
| Minnesota |
| Wyoming |
| Boise St. |
| Washington St. |
Process: The PiRate Ratings use a combination of NET Rankings, Computer Rankings, Strength of Schedule, Strength of Wins, The Eye-Test, and unfortunately Politics to attempt to mimic what the NCAA Selection Committee does leading up to Selection Sunday.
The Pi-Rate Ratings 