| Date | 1/3/2022 | |||||
| Seed | Team | Team | Team | Team | Team | Team |
| 1 | Baylor | Purdue | Arizona | Gonzaga | ||
| 2 | Houston | Duke | Kansas | Auburn | ||
| 3 | Kentucky | LSU | Tennessee | Villanova | ||
| 4 | Texas | Illinois | Michigan St. | USC | ||
| 5 | Ohio St. | Alabama | UCLA | Connecticut | ||
| 6 | Texas Tech | Loyola (Chi.) | Iowa | Xavier | ||
| 7 | Iowa St. | Providence | Seton Hall | Colorado St. | ||
| 8 | Virginia Tech | BYU | North Carolina | Florida | ||
| 9 | Michigan | Wisconsin | San Francisco | Mississippi St. | ||
| 10 | Oklahoma | Saint Mary’s | Indiana | Clemson | ||
| 11 | West Virginia | Memphis | Northwestern | Minnesota | Arkansas | Florida St. |
| 12 | Chattanooga | Davidson | Belmont | UAB | ||
| 13 | Iona | New Mexico St. | Ohio | Towson | ||
| 14 | Wagner | Oakland | Navy | South Dakota St. | ||
| 15 | Vermont | UC-Irvine | Liberty | Princeton | ||
| 16 | Georgia St. | Nicholls St. | Southern Utah | Texas Southern | Campbell | Howard |
First Four Out
| San Diego St. |
| Central Florida |
| Creighton |
| TCU |
Next Four Out
| Wake Forest |
| Boise St. |
| Washington St. |
| Texas A&M |
The Pi-Rate Ratings 