Saturday, March 20, 2021
| Favorite | Underdog | Spread |
| Gonzaga | Norfolk St. | 29.8 |
| Oklahoma | Missouri | 0.9 |
| Creighton | UCSB | 6.6 |
| Virginia | Ohio | 6.1 |
| USC | Drake | 5.1 |
| Kansas | Eastern Washington | 9.6 |
| Oregon | VCU | 0.7 |
| Iowa | Grand Canyon | 15.6 |
| Michigan | Texas Southern | 24.9 |
| LSU | St. Bonaventure | 0.2 |
| Colorado | Georgetown | 4.6 |
| Florida St. | UNCG | 10.0 |
| BYU | UCLA | 3.9 |
| Texas | Abilene Christian | 7.2 |
| Connecticut | Maryland | 2.2 |
| Alabama | Iona | 19.2 |
The Pi-Rate Ratings 