| Date | 3/13/2021 | |||||
| Seed | Team | Team | Team | Team | Team | Team |
| 1 | Gonzaga | Baylor | Michigan | Illinois | ||
| 2 | Ohio St. | Alabama | Iowa | Oklahoma St. | ||
| 3 | Houston | Arkansas | Kansas | Texas | ||
| 4 | Florida St. | Purdue | West Virginia | Virginia | ||
| 5 | Tennessee | Creighton | Colorado | Villanova | ||
| 6 | Oregon | USC | Texas Tech | Missouri | ||
| 7 | LSU | Oklahoma | Wisconsin | Clemson | ||
| 8 | BYU | Florida | Loyola (Chi.) | North Carolina | ||
| 9 | Rutgers | San Diego St. | Virginia Tech | Connecticut | ||
| 10 | St. Bonaventure | Georgia Tech | VCU | Maryland | ||
| 11 | Wichita St. | Michigan St. | UCLA | Louisville | ||
| 12 | Western Ky. | Winthrop | Syracuse | Drake | Utah St. | Ole Miss |
| 13 | UCSB | Liberty | UNCG | Colgate | ||
| 14 | Buffalo | Morehead St. | Abilene Christian | E. Washington | ||
| 15 | Cleveland St. | Grand Canyon | Oral Roberts | Drexel | ||
| 16 | Iona | Mount St. Mary’s | Appalachian St. | Hartford | Norfolk St. | Prairie View A&M |
First Four Out–Alternates
69 Saint Louis
70 Colorado St.
71 Boise St.
72 Xavier
Potential Bubble Busters: Memphis. Georgetown, and Oregon St.
The Pi-Rate Ratings 