Wednesday, March 3, 2021
| Home | Visitor | Spread |
| La Salle | Saint Joseph’s | 0.6 |
| George Washington | Fordham | 4.3 |
| Tulane | Wichita St. | -4.5 |
| Syracuse | Clemson | 0.8 |
| Notre Dame | NC St. | 2.4 |
| Florida St. | Boston College | 14.9 |
| Seton Hall | Connecticut | 0.2 |
| St. John’s | Providence | 2.6 |
| Villanova | Creighton | 1.6 |
| Eastern Washington | Idaho St. | 13.7 |
| Penn St. | Minnesota | 3.1 |
| Northwestern | Maryland | -2.6 |
| North Carolina A&T | South Carolina St. | 12.0 |
| North Carolina Central | Florida A&M | 0.4 |
| Colorado St. | New Mexico | 18.8 |
| UNLV | San Diego St. | -12.3 |
| Wagner | Merrimack | 6.1 |
| Belmont | SIU Edwardsville | 16.4 |
| Morehead St. | Southeast Missouri St. | 8.7 |
| Utah | Oregon St. | 3.8 |
| Oregon | UCLA | 2.4 |
| USC | Stanford | 7.7 |
| Boston U | Lehigh | 7.2 |
| Florida | Missouri | 4.9 |
| Texas A&M | Mississippi St. | -3.7 |
| Sam Houston St. | Texas A&M-CC | 14.7 |
| New Orleans | Northwestern St. | 3.0 |
| Houston Baptist | Incarnate Word | 0.4 |
| Central Arkansas | Southeast Louisiana | 1.5 |
| Stephen F. Austin | Abilene Christian | -3.1 |
The Pi-Rate Ratings 