| Thursday, September 24 |
| Time ET | Network | Home | Visitors | Entertainment Value |
| 7:30 PM | ESPN | S. Alabama | UAB | USA has revenge for last year’s 35-3 loss at UAB |
| | | | |
| Friday, September 25 |
| Time ET | Network | Home | Visitors | Entertainment Value |
| 8:00 PM | CBSSN | UTSA | Middle Tenn. | UTSA might have its best ever FBS team |
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| Saturday, September 26 |
| Time ET | Network | Home | Visitors | Entertainment Value |
| 12:00 PM | SEC | Auburn | Kentucky | One of the top games of the day |
| 12:00 PM | ABC | Wake Forest | Notre Dame | Irish looking to go to 2-0 in ACC |
| 12:00 PM | ESPN | Ole Miss | Florida | Debut of Lane Kiffin in Oxford |
| 12:00 PM | Fox | Oklahoma | Kansas St. | Sooners need to win big, or Big 12 has issues |
| 12:00 PM | ESPN2 | Louisiana | Ga. Southern | UL now the premier team in SBC |
| 12:00 PM | FSN | Syracuse | Ga. Tech | SU needs some offense. Tech has turnover issues |
| 12:00 PM | ESPNU | Charlotte | Ga. State | Two decent 0-1 teams |
| 12:00 PM | ACC | Pittsburgh | Louisville | Pitt could make some ACC noise with a win here |
| 12:30 PM | FS1 | TCU | Iowa St. | Loser of this game likely headed to losing record |
| 1:00 PM | ESPN3 | Liberty | Florida Int’l. | One of the better G5 games this week |
| 2:30 PM | Stadium | Southern Miss. | Tulane | Both teams blew large leads last week |
| 3:30 PM | CBS | LSU | Mississippi St. | Debut of Mike Leach with MSU/ LSU no Burrow |
| 3:30 PM | ESPN | Cincinnati | Army | Winner here has shot at G5 spot in NY6 |
| 3:30 PM | Fox | Texas Tech | Texas | Can Longhorns keep pace with OU |
| 3:30 PM | ABC | Oklahoma St. | West Va. | Okie St. players not on the same page last week |
| 3:30 PM | ESPN2 | Arkansas St. | Tulsa | Tulsa expected to bounce. ASU could win by TD+ |
| 3:30 PM | ESPNU | UL Monroe | UTEP | Two very weak G5 teams headed nowhere |
| 4:00 PM | SEC | Arkansas | Georgia | Debut of Sam Pittman at Arky;UGa a big favorite |
| 4:00 PM | ACC | Virginia | Duke | UVa finally gets to play. Duke already 0-2 |
| 6:00 PM | FSN | Boston College | Texas St. | BC looked like a rejuvenated team with great TEs |
| 6:00 PM | CBSSN | Florida Atlantic | USF | Nice in-state rivalry game but little more than that |
| 7:00 PM | ESPN | Missouri | Alabama | MO with 11 Covids at the wrong time |
| 7:00 PM | ESPN3 | Louisiana Tech | Houston Baptist | LT might not be overly sharp in this game |
| 7:30 PM | ABC | Miami (Fla.) | Florida St. | Game of the Night. Miami looked great vs. UL |
| 7:30 PM | SEC | S. Carolina | Tennessee | Closest SEC matchup of the day |
| 7:30 PM | SEC-A | Texas A&M | Vanderbilt | Worst SEC mismatch of the day |
| 7:30 PM | ESPNU | Baylor | Kansas | Baylor playing Game 1. KU wishes it was the same |
| 8:00 PM | ACC | Va. Tech | NC St. | First game for VT; second game for NC St. |
| 10:15 PM | ESPN | BYU | Troy | Worth staying up late for. Both 1-0 impressively |
The Pi-Rate Ratings 