Due to time constraints this week, the PiRates were not able to put out their selections on Thursday. Here are their picks for the weekend.
| PiRate | Selections | For | Nov. 6-7, 2015 |
| Home | Visitor | Line | Our Pick |
| UTEP | Rice | -6.5 | Rice |
| West Virginia | Texas Tech | 8 | Texas Tech |
| Georgia St. | UL-Lafayette | -1.5 | UL-Lafayette |
| Indiana | Iowa | -7 | Indiana |
| Florida | Vanderbilt | 21 | Florida |
| Houston | Cincinnati | 8.5 | Cincinnati |
| Massachusetts | Akron | -2.5 | Akron |
| Northwestern | Penn St. | 2.5 | Penn St. |
| Colorado | Stanford | -16.5 | Colorado |
| Clemson | Florida St. | 11.5 | Florida St. |
| Alabama | LSU | 7 | LSU |
| Middle Tennessee | Marshall | 3 | Marshall |
| N. Y. Jets | Jacksonville | 7.5 | Jacksonville |
| New Orleans | Tennessee | 7.5 | New Orleans |
| New England | Washington | 14 | New England |
| Indianapolis | Denver | -4.5 | Denver |
| Dallas | Philadelphia | -2.5 | Philadelphia |
The Pi-Rate Ratings 